Scientists in the Robia lab use biochemical and biophysical methods to investigate transporter conformational changes in order to understand mechanisms of transporter function and regulation. In particular, we take advantage of methods such as fluorescence resonance energy transfer (FRET), fluorescence correlation spectroscopy, fluorescence lifetime analysis, and molecular dynamics simulations to discover how transporters move and interact with their regulatory partners.

We are particularly interested in SERCA function in the context of human disease, especially heart failure, which is associated with impaired cardiac calcium handling. 

Research in the Robia Lab has been supported by the National Institutes of Health (National Heart, Lung, and Blood InstituteNational Institute of Biomedical Imaging and Bioengineering), and the American Heart Association.